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Hypersensitivity to the drug, patients in whom Aspirin and other Non-Steroidal Anti-Inflammatory Drugs induce the symptoms of allergy.
SEFDENE 20 is contraindicated: in patients with severe heart failure and; for the treatment of peri-operative pain in the setting of coronary artery bypass graft surgery.
History of gastrointestinal bleeding or perforation, related to previous NSAIDs therapy; active, or history of recurrent peptic ulcer/haemorrhage.
The third trimester of pregnancy, because of risks of premature closure of the ductus arteriosus, and prolonged parturition.
